| 目錄號 | MZ0701-100MG | 售價 | 2150.00元 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 規格 | 100mg | 運輸溫度 | 室溫運輸 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 其他名稱 | Flagecidin; Wuningmeisu C; NSC76712; AI350846; 回香霉素； | 保存溫度 | 2-8ºC干燥保存，或置于-20ºC長期干燥保存！ | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| CAS號 | 22862-76-6 | 有效期 | 2年 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 應用 | 抗生素；JNK激活劑 | 訂購數量 |
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產品簡介: Anisomycin 茴香霉素
搜索關鍵詞： Anisomycin茴香霉素；Flagecidin；Protein synthesis inhibitor蛋白合成抑制劑；JNK activator JNK激活劑；SP600125；CAS NO：22862-76-6；
產品訂購：更大包裝或產品技術問題，請來電/在線咨詢，電話：021-54736159 。
產品描述： 茴香霉素（Anisomycin），來源于灰色鏈霉菌（Streptomyces griseolus）的吡咯烷抗生素，是一種有效的蛋白合成抑制劑，通過抑制真核生物核糖體的肽酰轉移酶活性來發揮作用。據報道能誘導許多細胞的凋亡發生，包括早幼粒細胞白血病細胞、Jurkat細胞、心室肌細胞和結腸腺癌細胞。啟動胞內信號和立早基因誘導。 茴香霉素是強效的JNK激活劑，活化MAP激酶（JNK/SAPK和p38/RK）。作為一種有效的信號通路激動劑，選擇性引發即刻早期基因誘導的同源性脫敏（c-fos，fosB，c-jun，junB和junD）。茴香霉素（30mg/kg）表現出優于環孢霉素A（MZ2501-10MG）的免疫抑制活性，阻斷皮膚移植小鼠的T細胞增殖。
產品特性
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濃度 |
1mg |
5 mg |
10mg |
|
1mM |
3.7693 mL |
18.8466 mL |
37.6932 mL |
|
5mM |
0.7539mL |
3.7693 mL |
7.5386 mL |
|
10mM |
0.3769 mL |
1.8847 mL |
3.7693 mL |
|
50mM |
0.0754 mL |
0.3769 mL |
0.7539mL |
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文獻1，Yan J et al. c-Jun N-terminal kinase activation contributes to reduced connexin43 and development of atrial arrhythmias. Cardiovasc Res. 2013 Mar 1;97(3):589-97. PMID: 23241357 體外研究（細胞實驗）： 細胞類型（Cell types）：Mouse atrial myocyte line (HL-1) 實驗方法（Assay）：Atrial myocytes were treated with 50 ng/mL anisomycin with or without 2 μmol/L SP600125, or a corresponding amount of the DMSO solvent for 16 or 24 h followed by biochemical or optical mapping studies. 體內研究（動物模型）： 動物模型（Animal Model）：Young (6 months) and aged (54 months) male New Zealand White rabbits 實驗方法（Assay）：LA effective refractory period (AERP) was measured using an S1-S2 pacing protocol and atrial arrhythmias (AT/AF) were induced using burst pacing in open-chest heartsin young rabbits with (n = 4) or without (n = 5)anisomycin treatment (15 mg/kg, iv, four treatments over 9 days)and aged rabbits without anisomycin treatment (n = 6). |
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文獻2，Lattal KM et al. Behavioral impairments caused by injections of the protein synthesis inhibitor anisomycin after contextual retrieval reverse with time. Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13):4667-72. PMID: 15070775 體內研究（動物模型）： 動物模型（Animal Model）：Male C57BL/6 mice (8-12 weeks old) 配制方法（Formulation）：Anisomycin wasdiluted in salineand dissolved in 1 M HCl. The pH was adjusted to≈7 with 1 M NaOH. 實驗方法（Assay）：Mice received subcutaneous injections of 50 or 75 mg of anisomycin/kg of body weight or an equivalent volume of saline in the first experiment. Injections in all other experiments were 50 mg/kg of anisomycin or an equivalent volume of saline. |
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文獻3，Guo Xet al. GSK3β regulates AKT-induced central nervous system axon regeneration via an eIF2Bε-dependent, mTORC1-independent pathway. Elife. 2016 Mar 14;5:e11903.PMID: 26974342. 體內研究（動物模型）： 動物模型（Animal Model）： 配制方法（Formulation）：Anisomycin was dissolved inDMSO to prepare a stock solution anddiluted inPBS before each administration. 實驗方法（Assay）：Anisomycin (30 mg/kg body weight)or vehicle was injected subcutaneously daily after optic nerve crush. To inhibit OPP incorporation, anisomycin (50 μg/ml) was injected intravitreally 1 hr before and together with OPP administration. |
相關產品：更大包裝或產品技術問題，請來電/在線咨詢，電話：021-54736159 。
|
貨號 |
產品名稱 |
規格 |
|
MZ0701-5MG |
Anisomycin 茴香霉素 |
5mg |
|
MZ0702-10MG |
SP600125 JNK抑制劑 |
10mg |
|
MZ0201-10MG |
Rapamycin (Sirolimus) 雷帕霉素（西羅莫司） |
10mg |
|
MZ2501-10MG |
Cyclosporin A (CsA) 環孢霉素A |
10mg |
注意事項
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上海懋康生物科技有限公司是一家涉足于生命科學和生物技術領域研究的試劑、儀器和實驗室消耗品與實驗服務工作，主要從事細胞生物學、植物學、分子生物學、免疫學、生物化學、蛋白組學。生物制藥與診斷試劑研發生產等領域。 本公司秉承“以人為本，以誠為信、合同守信”的經營理念。堅持"品質保障"的原則為廣大客戶提供優質產品。
